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<p><strong>杜鑫辉</strong></p>
<p>河南省肿瘤医院骨科 副主任医师</p>
<p><a target="_blank" rel="noopener" href="https://orcid.org/0000-0002-7411-3214">https://orcid.org/0000-0002-7411-3214</a></p>
<p><strong>学习经历</strong>：<br>    2012年6月硕士毕业于上海交通大学附属第六人民医院，外科学（骨科）专业。<br>    2017年2月至2018年12月期间在美国休斯顿贝勒医学院及Methodist   hospital访问学习。<br><strong>学术任职</strong>：<br>    中国抗癌协会肉瘤专业委员会四肢学组 委员<br>    河南省抗癌协会肉瘤专委会 常委<br>    河南省脊柱脊髓损伤协会脊柱肿瘤委员会 秘书<br>    河南省中西医结合学会骨伤分会骨与软组织肿瘤专业委员会委员<br>    近年发表SCI及中华系列文章累及10余篇<br>    Frontiers in Oncology及Cancer Medicine杂志审稿人<br><strong>擅长领域</strong>：<br>    骨与软组织肉瘤及转移瘤的诊疗<br><strong>科研项目及成果：</strong><br>    主持省卫健委科技攻关项目二项<br>    发表中英文文章20余篇，其中一作发表中华系列杂志3篇，SCI文章8篇。<br>开展新技术6项，其中国内领先技术2项。</p>
<h2 id="科研项目"><a href="#科研项目" class="headerlink" title="科研项目"></a>科研项目</h2><h3 id="在研"><a href="#在研" class="headerlink" title="在研"></a>在研</h3><ol>
<li>人工智能辅助下肉瘤三维数字化建模及其临床应用的安全性及有效性研究，2024年科技攻关项目，河南省科技厅 NO.242102310016，项目负责人：杜鑫辉。 项目起止时间：2024.1.1-2024.12.31</li>
<li>核糖体蛋白L23通过N-cadherin调控骨肉瘤EMT及转移的机制研究，2022年，河南省卫生健康委员会， NO.LHGJ20220194，项目负责人：杜鑫辉。 起止时间：2023.1.1-2024.12.31</li>
</ol>
<h3 id="已结项"><a href="#已结项" class="headerlink" title="已结项"></a>已结项</h3><ol>
<li>OVAAL&#x2F;DHX36在恶性黑色素瘤转移中的机制研究，2021年科技攻关项目，河南省科技厅 NO.212102310617,项目负责人：杜鑫辉。项目起止时间：202.1.1-2023.12.31</li>
</ol>
<p><strong>科研方向</strong><br><strong>1.	临床科研</strong><br>临床科研的开展直接服务于患者，主要目的为优化手术方式、降低围术期并发症、提高总体治疗效果。<br>本课题组临床科研方向主要包括<strong>数字化技术</strong>及<strong>创新术式</strong>在肉瘤切除及重建中的应用研究。<br>我们使用数字化技术对肿瘤及周围重要组织进行三维建模以用于新辅助治疗效果评估、肿瘤边界评估、手术方案设计、临床教学等。<br>创新术式主要包括骨盆三区的<strong>“PSM重建技术”</strong>及复杂骨肿瘤的<strong>“软化”切除技术</strong>等。<br><strong>2.	基础研究</strong><br>基础研究的开展以临床问题为导向，以多组学探索肿瘤的生物学行为及分子改变为主要手段，为深入研究恶性肿瘤的发病机制及探索新的阻断药物或分子标志物提供新的思路。<br>本课题组基础研究方向主要包括<strong>恶性肿瘤转移的分子机制</strong>及<strong>肿瘤微环境</strong>研究。<br>我们利用生信技术、恶性肿瘤体外及小鼠动物模型、分子生物学技术、基因敲低及过表达技术等发现了核糖体蛋白RPLP1在骨肉瘤转移中发挥关键作用。<br>肿瘤微环境中的肿瘤与周围细胞（肿瘤相关成纤维细胞、巨噬细胞、血小板）的交互及基质蛋白等均参与肿瘤的转移与免疫逃逸。</p>
<p><strong>在研方向</strong></p>
<ul>
<li><p>骨肉瘤转移机制研究</p>
</li>
<li><p>肉瘤的高通量多组学分析</p>
</li>
<li><p>数字化技术辅助下肉瘤精准切除与评估</p>
</li>
<li><p>罕见肿瘤模型的构建及鉴定</p>
<ul>
<li><p>恶性黑色素瘤</p>
</li>
<li><p>脊索瘤</p>
</li>
<li><p>副脊索瘤</p>
</li>
<li><p>骨肉瘤</p>
</li>
<li><p>软骨肉瘤</p>
</li>
<li><p>UPS</p>
</li>
<li><p>滑膜肉瘤</p>
</li>
</ul>
</li>
</ul>
<p><strong>发表文章：</strong></p>
<p><strong>2023</strong></p>
<p>[1]	<strong>Du X</strong>, Wei H, Zhang B, Wang B, Li Z, Pang LK, Zhao R and Yao W. Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities. Front Oncol 2023; 13: 1117867. <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/Molecular%20mechanisms%20of%20osteosarcoma%20metastasis%20and%20possible%20treatment%20opportunities.pdf">全文下载</a></strong><br>[2]	Wei H, <strong>Du X</strong>, Zhao H, Sun P and Yang J. Propofol Regulates ER Stress to Inhibit Tumour Growth and Sensitize Osteosarcoma to Doxorubicin. Int J Clin Pract 2023; 2023: 3093945. <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/propofol%20paper.pdf">全文下载</a></strong><br>[3]	<strong>Du X</strong>, Wei H, Zhang B, Gao S, Li Z and Yao W. The pedicled sartorius flap and mesh (PSM) technique vs no reconstruction in repairing the defect after type III pelvic bone tumor resection: a retrospective study. World J Surg Oncol 2023; 21: 14. <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/PSM%20pelvic.pdf">全文下载</a></strong><br>[4] Du X, Wei H, Zhang B, Pang LK, Zhao R, Zhang XD and Yao W. Unveiling the prognostic implications of RPLP1 upregulation in osteosarcoma. Am J Cancer Res 2023; 13: 4822-4831. <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/Unveiling%20the%20prognositc%20implications%20of%20RPLP1%20upregulation%20in%20osteosarcoma.pdf">全文下载</a></strong><br>[5] Boya Zhang， Xinhui Du , Yichao Fan,Guoxin Qu, Lon Kai Pang, Ruiying Zhao, Weitao Yao,DLX2 promotes osteosarcoma epithelial-mesenchymal transition and doxorubicin resistance by enhancing HOXC8-CDH2 axis. iScience, 2023 Oct 19, <a target="_blank" rel="noopener" href="https://doi.org/10.1016/j.isci.2023.108272">https://doi.org/10.1016/j.isci.2023.108272</a>. <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/DLX2%20paper.pdf">全文下载</a></strong></p>
<p><strong>2023以前</strong><br>[1] <strong>Du X-H</strong>, Wei H, Zhang P, Yao W-T, Cai Q-Q. Heterogeneity of Soft Tissue Sarcomas and Its Implications in Targeted Therapy. Front Oncol. 2020; 10:564852. doi:10.3389&#x2F;fonc.2020.564852. <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/papers/Heterogeneity%20of%20Soft%20Tissue%20Sarcomas%20and%20Its%20Implications%20in%20Targeted%20Therapy.pdf">全文下载</a></strong><br>[2]	<strong>Du X</strong>, Wei H, Zhang B, Gao S, Li Z, Cheng Y, Fan Y, Zhou X and Yao W. Experience in utilizing a novel 3D digital model with CT and MRI fusion data in sarcoma evaluation and surgical planning. J Surg Oncol 2022; 126: 1067-1073.<strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/experience%20in%20utilizing%20a%20novel%203d%20d%20source%20j%20surg%20oncol%20so%202022.pdf">全文下载</a></strong><br>[3]	<strong>Du XH</strong>, Wei H, Qu GX, Tian ZC, Yao WT and Cai QQ. Gene expression regulations by long noncoding RNAs and their roles in cancer. Pathol Res Pract 2020; 216: 152983.<strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/gene%20expression%20regulations%20by%20long%20noncoding%20rnas%20and%20their%20roles%20in%20cancer%20.pdf">全文下载</a></strong><br>[4]	<strong>杜鑫辉</strong>, 王帮民, 张博雅, 刘新, 田志超 and 姚伟涛. CT、MRI图像融合及计算机模拟技术在辅助骨盆Ⅲ、Ⅳ区恶性肿瘤手术中的疗效分析. 中华外科杂志 2022; 60: 567-572.<strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/112139-20220127-00040-CT%E3%80%81MRI%E5%9B%BE%E5%83%8F%E8%9E%8D%E5%90%88%E5%8F%8A%E8%AE%A1%E7%AE%97%E6%9C%BA%E6%A8%A1%E6%8B%9F%E6%8A%80%E6%9C%AF%E5%9C%A8%E8%BE%85%E5%8A%A9%E9%AA%A8%E7%9B%86%E2%85%A2%E3%80%81%E2%85%A3%E5%8C%BA%E6%81%B6%E6%80%A7%E8%82%BF%E7%98%A4%E6%89%8B%E6%9C%AF%E4%B8%AD%E7%9A%84%E7%96%97%E6%95%88%E5%88%86%E6%9E%90-2022_5_4%2022%2019%2028.pdf">全文下载</a></strong><br>[5] <strong>杜鑫辉</strong>，王帮民，程瑜,等. 神经穿透素1对滑膜肉瘤细胞侵袭性的影响及其机制. 中华实验外科杂志，2022，39(04):694-696. DOI:10.3760&#x2F;cma.j.cn421213-20210807-01231. <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/%E7%A5%9E%E7%BB%8F%E7%A9%BF%E9%80%8F%E7%B4%A01%E5%AF%B9%E6%BB%91%E8%86%9C%E8%82%89%E7%98%A4%E7%BB%86%E8%83%9E%E4%BE%B5%E8%A2%AD%E6%80%A7%E7%9A%84%E5%BD%B1%E5%93%8D%E5%8F%8A%E5%85%B6%E6%9C%BA%E5%88%B6.pdf">全文下载</a></strong><br>[6] <strong>杜鑫辉</strong>，王帮民，程瑜,等. 长链非编码RNA MALAT1对滑膜肉瘤细胞增殖及侵袭的影响及其机制. 中华实验外科杂志，2022，39(03):538-540. DOI:10.3760&#x2F;cma.j.cn421213-20210807-01230. <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/%E9%95%BF%E9%93%BE%E9%9D%9E%E7%BC%96%E7%A0%81RNA%20MALAT1%20%E5%AF%B9%E6%BB%91%E8%86%9C%E8%82%89%E7%98%A4%E8%82%89%E7%98%A4%E5%A2%9E%E6%AE%96%E5%8F%8A%E4%BE%B5%E8%A2%AD%E7%9A%84%E5%BD%B1%E5%93%8D%E5%8F%8A%E6%9C%BA%E5%88%B6.pdf">全文下载</a></strong><br>[7] 魏华，<strong>杜鑫辉</strong>，赵华平,等. 丙泊酚对人黑色素瘤细胞增殖、侵袭及迁移能力的影响及COX-2&#x2F;PGE2&#x2F;MMP信号通路在其中的作用. 中华麻醉学杂志，2022，42(05):551-555. DOI:10.3760&#x2F;cma.j.cn131073.20220110.00509. <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/%E4%B8%99%E6%B3%8A%E9%85%9A%E5%AF%B9%E4%BA%BA%E9%BB%91%E8%89%B2%E7%B4%A0%E7%98%A4%E7%BB%86%E8%83%9E%E5%A2%9E%E6%AE%96%E3%80%81%E4%BE%B5%E8%A2%AD%E5%8F%8A%E8%BF%81%E7%A7%BB%E8%83%BD%E5%8A%9B%E7%9A%84%E5%BD%B1%E5%93%8D%E5%8F%8ACOX-2_PGE2_MMP%E4%BF%A1%E5%8F%B7%E9%80%9A%E8%B7%AF%E5%9C%A8%E5%85%B6%E4%B8%AD%E7%9A%84%E4%BD%9C%E7%94%A8.pdf">全文下载</a></strong><br>[10] <strong>X. H. Du</strong>, H. Wei, P. Li and W. T. Yao. Artificial Intelligence (AI) Assisted CT&#x2F;MRI Image Fusion Technique in Preoperative Evaluation of a Pelvic Bone Osteosarcoma. Front Oncol 2020;10:1209. <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/papers/CTMRI%20fusion%20case.pdf">全文下载</a></strong></p>
<p>魏华 瑞玛佐伦paper <strong><a href="https://gitee.com/drduxinhui/pefect_day/raw/master/img/%E7%91%9E%E9%A9%AC%E5%94%91%E4%BB%91%E5%A4%8D%E5%90%88%E9%98%BF%E8%8A%AC%E5%A4%AA%E5%B0%BC%E7%94%A8%E4%BA%8E%E8%A1%B0%E5%BC%B1%E8%80%81%E5%B9%B4%E6%82%A3%E8%80%85%E8%83%83%E9%95%9C%E6%A3%80%E6%9F%A5%E6%9C%AF%E7%9A%84%E6%95%88%E6%9E%9C.pdf">全文下载</a></strong></p>
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